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MRS 1754

CAS No. 264622-58-4

MRS 1754( —— )

Catalog No. M26764 CAS No. 264622-58-4

MRS 1754 is a selective antagonist radioligand for the A2B adenosine receptor. It has a very low affinity for A1 and A3 receptors of both humans and rats.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    MRS 1754
  • Note
    Research use only, not for human use.
  • Brief Description
    MRS 1754 is a selective antagonist radioligand for the A2B adenosine receptor. It has a very low affinity for A1 and A3 receptors of both humans and rats.
  • Description
    MRS 1754 is a selective antagonist radioligand for the A2B adenosine receptor. It has a very low affinity for A1 and A3 receptors of both humans and rats.(In Vitro):The Ki value for displacement of [3H]MRS 1754 binding to human A2B receptors expressed in HEK-293 cell membranes is 1.45±0.21 nM. The most effective displacer of [3H]MRS 1754 binding is MRS 1754. .
  • In Vitro
    The most potent displacer of [3H]MRS 1754 binding is MRS 1754. The Ki value for displacement of [3H]MRS 1754 binding to human A2B receptors expressed in HEK-293 cell membranes is 1.45±0.21 nM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    JAK1| JAK3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    264622-58-4
  • Formula Weight
    486.532
  • Molecular Formula
    C26H26N6O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 15 mg/mL (30.83 mM)
  • SMILES
    CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCC(=O)Nc2ccc(cc2)C#N)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Li Hui, et al.Preparation of phenylaminopyrimidinylaminooxobenzooxazole derivatives for use as JAK kinase inhibitors. WO2012015972A1
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